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Papers of the Week


Papers: 23 Mar 2019 - 29 Mar 2019


2019 Jun


Neuropeptides


75

Autophagy dysfunction in neuropathic pain.

Authors

Liu X, Zhu M, Ju Y, Li A, Sun X
Neuropeptides. 2019 Jun; 75:41-48.
PMID: 30910234.

Abstract

Autophagy is a lysosomal degradation pathway that maintains tissue homeostasis by recycling damaged and aged cellular components, which plays important roles in development of the nervous system, as well as in neuronal function and survival. In addition, autophagy dysfunction underlies neuropathic pain. Thus, the modulation of autophagy can alleviate neuropathic pain. Here, we describe the definition, mechanisms of autophagy and neuropathic pain. On this basis, we further discuss the role of autophagy dysfunction in neuropathic pain. This review updates our knowledge on autophagy mechanisms which propose potential therapeutic targets for the treatment of neuropathic pain.