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Papers of the Week


Papers: 26 Jan 2019 - 1 Feb 2019


Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2019


Handb Exp Pharmacol


255

CGRP in Animal Models of Migraine.

Authors

Wattiez A-S, Wang M, Russo AF
Handb Exp Pharmacol. 2019; 255:85-107.
PMID: 30689086.

Abstract

With the approval of calcitonin gene-related peptide (CGRP) and CGRP receptor monoclonal antibodies by the Federal Drug Administration, a new era in the treatment of migraine patients is beginning. However, there are still many unknowns in terms of CGRP mechanisms of action that need to be elucidated to allow new advances in migraine therapies. CGRP has been studied both clinically and preclinically since its discovery. Here we review some of the preclinical data regarding CGRP in animal models of migraine.