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Papers of the Week


2020 Apr 23


Perit Dial Int

Persistent exit-site infection in peritoneal dialysis – An unrecognized window to abdominal viscera.

Authors

Domingos A T, Malho Guedes A, Mendes F B, Vidinha J, Bernardo I, Neves P L
Perit Dial Int. 2020 Apr 23:896860820920134.
PMID: 32323638.

Abstract

Exit-site (ES) infection is a common complication in peritoneal dialysis (PD). . is particularly difficult to treat, and catheter removal should be considered in persistent infections. The authors present a chronic ES infection resistant to directed antibiotic therapy in which catheter salvage was not possible. Removal was very difficult due to the presence of white sponge-like tissue with petrous consistency surrounding the catheter, all the way into the peritoneum. Histology revealed well-differentiated adenocarcinoma infiltrates. Abdominal computed tomography scan revealed a solid pancreatic (tail) lesion, nodular images on the greater epiploon, an adnexal lesion and a hepatic solid lesion, consistent with metastasis. The patient was referred for palliative care but maintained PD until untreatable pain and deterioration of general status aroused. Somewhere along the course of a chronic ES infection, the peritoneal catheter (and inflammation) was the metastatic path of an unknown pancreatic cancer, with neoplastic tissue reaching the skin. Catheter removal was crucial for diagnosis.