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Papers of the Week


2022 Mar 17


Nurs Res

Inflammatory and Immune Protein Pathways Possible Mechanisms for Pain Following Walking in Knee Osteoarthritis.

Authors

Klinedinst JN, Huang W, Nelson AK, Resnick B, Renn C, Kane MA, Dorsey SG
Nurs Res. 2022 Mar 17.
PMID: 35302959.

Abstract

Knee osteoarthritis affects nearly 30% of adults aged 60 or older and causes significant pain and disability. Walking is considered a "gold standard" treatment option for reducing knee osteoarthritis pain and maintaining joint mobility but does not reduce pain for all adults with knee osteoarthritis pain and may induce pain-particularly when starting a walking routine. The mechanism by which walking is helpful for knee osteoarthritis pain is unclear. Quantitative sensory testing has revealed that knee osteoarthritis pain has both peripheral and central components, which vary by individual.