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Primary Prevention of Chronic Pain


9 July 2021


The 2023 Global Year aims to raise awareness about integrative pain care and illustrate the knowns and unknowns of this important topic via different initiatives, including a fact sheet series and several webinars.

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One future approach to primary prevention of chronic pain may be public health interventions aimed at both the general population and high-risk groups.


Primary prevention of pain is defined as preventing acute pain, secondary prevention addresses the transition from acute to chronic pain and tertiary prevention aims to reduce the impact of chronic pain [5]. In the following, the evidence for primary prevention interventions for post-surgical pain and workplace injuries is summarized.

Primary Prevention of Pain in Research

Chronic post-surgical pain Surgical procedures are common, often cause acute pain, affect a large proportion of the population and are probably the most researched pain condition in relation to primary prevention [1]. Preventive measures include pre-habilitation, pre- and perioperative pharmacotherapy and anaesthesia as well as post-discharge interventions. Pre-habilitation, consisting mainly of aerobic and resistance exercise, may improve physical function, length of stay and pain following surgery compared with standard care (low quality of evidence) [8]. Patient education is assumed to reduce fear or anxiety of pain from surgical procedures, however, current low-quality evidence suggests that preoperative education alone may not improve post-operative pain, function and health-related quality of life or postoperative anxiety any more than usual care [6]. However, preoperative psychological interventions including information, cognitive interventions or relaxation strategies may have small, but significant positive effects on postoperative pain, length of stay, or negative affect (very low to low quality of evidence) [7]. 

The efficacy of pharmacotherapy and anaesthesia for preventing chronic pain after surgery was investigated and is discussed in detail in another fact sheet (see “Prevention of Chronic Post-Surgical Pain” Fact Sheet).

Investigation of post-discharge interventions to reduce severity of chronic pain after total knee arthroplasty, consisting mainly of physiotherapy, suggests that these interventions appear to be effective [15].

As indicated by recent flagship projects (but without an RCT supporting this so far) an interdisciplinary approach that includes pre-surgical, in-hospital post-surgical and out-of-hospital post-discharge interventions performed by a multi-professional “transitional pain service” seems promising to prevent chronic pain after surgery in patients at risk [4, 13]. As a prerequisite, prediction tools to identify patients at high risk for developing chronic pain after surgery are needed and many research groups are working on this [9].

Occupational interventions aim to reduce work-related incidents and injuries leading to acute pain. Interventions should address modifiable physical and psychological risk factors that increase significantly the odds of a new onset of back pain. These include exposure to manual tasks involving awkward positioning (OR 8.0, 95% CI 5.5–11.8) or being distracted during a task or activity (OR 25.0, 95% CI 3.4–184.5) or being fatigued (OR 3.7, 95% CI 2.2–6.3) [11]. However, there is moderate quality evidence that manual material handling advice and training with or without assistive devices does not prevent back pain or back pain‐related disability when compared to no intervention or alternative interventions [14]. 

Common occupational interventions include exercise alone (RR 0.65, 95%KI 0.50-0.86) or in combination with education (RR 0.55, 95% KI 0.41-0.74) that both reduce the risk of developing LBP in the first place (low to moderate quality of evidence) [12], findings supported by a recent overview of reviews [10]. Other occupational interventions such as education alone (booklets, back schools, videos), foot orthoses or shoe insoles or lumbar support (back belts, braces, chair back rests) had no effect on the incidence of LBP [10]. 

Physical ergonomic interventions include improving equipment and environment of the workplace to reduce the physical strain to the musculoskeletal system [3]. One meta-analysis found inconclusive low to moderate quality evidence for arm support with an alternative computer mouse in reducing the incidence of neck or shoulder or right upper limb musculoskeletal disorders, and very low-quality evidence that supplementary breaks reduce discomfort of the neck (MD −0.25; 95% CI −0.40 to −0.11), right shoulder or upper arm (MD −0.33; 95% CI −0.46 to −0.19), and right forearm or wrist or hand (MD -0.18; 95% CI -0.29 to -0.08) among office workers [3]. No effect on upper limb pain or discomfort was found for workstation adjustment and sit-stand desks [3]. 


Few studies explicitly address the efficacy and efficiency of primary prevention interventions for chronic pain highlighting the need for high quality research in this area. One future approach to primary prevention of chronic pain may be public health interventions aimed at both the general population and high-risk groups [5]. Public education may heighten awareness about pain and its health consequences, improve public knowledge about strategies that individuals can use to manage their own pain, and address disparities that exist in the experience of pain [2].


[1] Chapman, C. R., & Vierck, C. J. (2017). The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms. J Pain, 18(4), 359.e351-359.e338. doi:10.1016/j.jpain.2016.11.004

[2] Gatchel, R. J., Reuben, D. B., Dagenais, S., Turk, D. C., Chou, R., Hershey, A. D., . . . Horn, S. D. (2018). Research Agenda for the Prevention of Pain and Its Impact: Report of the Work Group on the Prevention of Acute and Chronic Pain of the Federal Pain Research Strategy. J Pain, 19(8), 837-851. doi:10.1016/j.jpain.2018.02.015

[3] Hoe, V. C. W., Urquhart, D. M., Kelsall, H. L., Zamri, E. N., & Sim, M. R. (2018). Ergonomic interventions for preventing work‐related musculoskeletal disorders of the upper limb and neck among office workers. Cochrane Database of Systematic Reviews(10). doi:10.1002/14651858.CD008570.pub3

[4] Huang, A., Azam, A., Segal, S., Pivovarov, K., Katznelson, G., Ladak, S. S., . . . Clarke, H. (2016). Chronic postsurgical pain and persistent opioid use following surgery: the need for a transitional pain service. Pain Manag, 6(5), 435-443. doi:10.2217/pmt-2016-0004

[5] IPRCC. (2018). Federal Pain Research Strategy. Retrieved from Federal Pain Research Strategy Overview website: https://www.iprcc.nih.gov/sites/default/files/iprcc/FPRS_Research_Recommendations_Final_508C.pdf

[6] McDonald, S., Page Matthew, J., Beringer, K., Wasiak, J., & Sprowson, A. (2014). Preoperative education for hip or knee replacement. Cochrane Database of Systematic Reviews, (5). Retrieved from http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003526.pub3/abstract doi:10.1002/14651858.CD003526.pub3

[7] Powell, R., Scott Neil, W., Manyande, A., Bruce, J., Vögele, C., Byrne-Davis Lucie, M. T., . . . Johnston, M. (2016). Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia. Cochrane Database of Systematic Reviews, (5). Retrieved from http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD008646.pub2/abstract doi:10.1002/14651858.CD008646.pub2

[8] Santa Mina, D., Clarke, H., Ritvo, P., Leung, Y. W., Matthew, A. G., Katz, J., . . . Alibhai, S. M. (2014). Effect of total-body prehabilitation on postoperative outcomes: a systematic review and meta-analysis. Physiotherapy, 100(3), 196-207. doi:10.1016/j.physio.2013.08.008

[9] Sipila, R., Estlander, A. M., Tasmuth, T., Kataja, M., & Kalso, E. (2012). Development of a screening instrument for risk factors of persistent pain after breast cancer surgery. Br J Cancer, 107(9), 1459-1466. doi:10.1038/bjc.2012.445

[10] Sowah, D., Boyko, R., Antle, D., Miller, L., Zakhary, M., & Straube, S. (2018). Occupational interventions for the prevention of back pain: Overview of systematic reviews. J Safety Res, 66, 39-59. doi:10.1016/j.jsr.2018.05.007

[11] Steffens, D., Ferreira, M. L., Latimer, J., Ferreira, P. H., Koes, B. W., Blyth, F., . . . Maher, C. G. (2015). What triggers an episode of acute low back pain? A case-crossover study. Arthritis Care Res (Hoboken), 67(3), 403-410. doi:10.1002/acr.22533

[12] Steffens, D., Maher, C. G., Pereira, L. S., Stevens, M. L., Oliveira, V. C., Chapple, M., . . . Hancock, M. J. (2016). Prevention of Low Back Pain: A Systematic Review and Meta-analysis. JAMA Intern Med, 176(2), 199-208. doi:10.1001/jamainternmed.2015.7431

[13] Tiippana, E., Hamunen, K., Heiskanen, T., Nieminen, T., Kalso, E., & Kontinen, V. K. (2016). New approach for treatment of prolonged postoperative pain: APS Out-Patient Clinic. Scand J Pain, 12, 19-24. doi:10.1016/j.sjpain.2016.02.008

[14] Verbeek, J. H., Martimo, K. P., Karppinen, J., Kuijer, P., Viikari‐Juntura, E., & Takala, E. P. (2011). Manual material handling advice and assistive devices for preventing and treating back pain in workers. Cochrane Database of Systematic Reviews(6). doi:10.1002/14651858.CD005958.pub3

[15] Wylde, V., Dennis, J., Gooberman-Hill, R., & Beswick, A. D. (2018). Effectiveness of postdischarge interventions for reducing the severity of chronic pain after total knee replacement: systematic review of randomised controlled trials. BMJ open, 8(2), e020368. doi:10.1136/bmjopen-2017-020368


Prof. Dr. Axel Schaefer
University of Applied Science and Arts
Faculty of Social Work and Health
Hildesheim, Germany


Brona M. Fullen, PhD
Associate Professor
UCD School of Public Health
Physiotherapy and Sports Science
Dublin, Ireland

Professor Esther Pogatzki-Zahn, MD, PhD
Department of Anesthesiology, Intensive Care and Pain Medicine
University Hospital Muenster
Muenster, Germany

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