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Dysynchiria is not a common feature of neuropathic pain



The 2024 Global Year will examine what is known about sex and gender differences in pain perception and modulation and address sex-and gender-related disparities in both the research and treatment of pain.

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Heidrun H. Krämer(a), Susann Seddigh(b), G. Lorimer Moseley(c), Frank Birklein(a)
(a) Department of Neurology, University of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany
(b) Department of Neurology, DRK Schmerz-Zentrum Mainz, Auf der Steig 16, 55131 Mainz, Germany
(c) Department of Physiology, Anatomy & Genetics & fMRIB Centre, University of Oxford, UK


Patients with chronic neuropathic pain (non-CRPS) and brush-evoked allodynia watched a reflected image of their corresponding but opposite skin region being brushed in a mirror. Unlike complex regional pain syndrome Type 1, this process did not evoke any sensation at the affected area (‘dysynchiria’). We conclude that central nociceptive sensitisation alone is not sufficient to cause dysynchiria in neuropathic pain. The results imply a difference in cortical pain processing between complex regional pain syndrome and other chronic neuropathic pain.

See full article at Euro J Pain 12,1 128-31

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