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Postdoctoral Fellow: Neuronal Ensembles in Brain Pathways in Chronic Pain

PRF Team


8 July 2024


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Molecular Pharmacology Department, Pharmacology Institute, Heidelberg, Germany

Name of the PI: Rohini Kuner

Email address: sfb1158office@pharma.uni-heidelberg.de

Website

Contract length: 2-4 years

Deadline of the application: October 31, 2024

Starting date: November 1, 2024

Project Summary: The precise basis of how pain is encoded in the brain remains unknown. Our past and recent work points to specificity of regions and pathways in mediating or modulating specific components of pain, such sensory, emotional and cognitive aspects. In this project, we aim to address neuronal ensembles, i.e., cohorts of specific and sparsely distributed neurons in the rodent brain, in key brain areas and study their plasticity as well as role in mouse models of acute and chronic pain.

Methods that will be used: In vivo electrophysiology in mouse brain (Neuropixel recordings), optogenetic manipulations, in vivo imaging, behavioral analyses in mice.

Cooperation partners: Prof. Thomas Kuner (Heidelberg University) and Prof. Markus Plober (TUM, Munich)

Eligibility qualifications: PhD in neurosciences or associated fields. A strong record in study of brain functions and rodent models is a must. Expertise in electrophysiology is desired.

Desirable skills: Electrophysiological analyses and/or in vivo imaging in rodent brain.

Enclosures: The following documents must be enclosed with your application as a single PDF file: updated CV with publications, motivation letter, copies of degree certificates.

Information for the applicant: For any updates and further information (e.g., change of deadline of the application), please visit the consortium website career section.

Project-related references:

Stegemann A, Liu S, Retana Romero OA, Oswald MJ, Han Y, Beretta CA, Gan Z, Tan LL, Wisden W, Gräff J, Kuner R. Prefrontal engrams of long-term fear memory perpetuate pain perception. Nature Neuroscience. doi: 10.1038/s41593-023-01291-x, 2023.

Gan, Z., Gangadharan V., L.L. Tan, C. Körber, H. Li, M. J. Oswald, J. Kang, J.M. Martin-Cortecero, D. Männich, A. Groh, T. Kuner, S. Wieland and Kuner, R. Layer-specific pain relief pathways originating from motor cortex. Science, 378(6626):1336-1343, 2022.

Oswald MJ, Han Y, Li H, Marashli S, Oglo DN, Ojha B, Naser PV, Gan Z, Kuner R. Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex. Nature Communications, 2022, 13(1):5014.

Tan LL, Oswald MJ, Heinl C, Retana Romero OA, Kaushalya SK, Monyer H, Kuner R. Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception. Nature Communications 28;10(1): 983, 2019.

Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, Sprengel R, Kuner T, Kuner R. A key role for a mid-cingulate cortex-posterior insula pathway in nociceptive hypersensitivity, Nature Neuroscience 20(11):1591-1601, 2017.

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