Editor’s note: This seminar is the latest event in a series of seminars launched in May 2020 to help keep the pain research community connected during the COVID-19 pandemic and to provide all members of our community with virtual educational opportunities. The seminar series is supported by the Center for Advanced Pain Studies at the University of Texas at Dallas, US.
The IASP Pain Research Forum will host a seminar with Geoffroy Laumet, PhD, Michigan State University, US, on Monday, November 16, 2020, noon-1:00 p.m. Eastern Standard Time (US)/5-6:00 p.m. GMT/6-7:00 p.m. CET. A Q&A session moderated by Edgar Alfonso Romero-Sandoval, MD PhD, Wake Forest University School of Medicine, US, will follow the presentation.
A recording of this webinar will soon be freely available to IASP members at the IASP Pain Education Resource Center (PERC).
Here is an abstract from the presenter
Considerable advances have been made in understanding the neuronal molecular mechanisms leading to amplification of nociceptive signals and the development of chronic pain. An important contribution of immune cells in driving the neuroplasticity associated with chronic pain is now better appreciated. However, the contribution of immune cells and their mediators in the prevention of chronic pain and its resolution is under-investigated. This seminar will discuss work from my lab in this area. We have found an unexpected role of CD8+ T cells in the resolution of pain and the prevention of chronic pain. Mechanistically, CD8+ T cells promote the expression of the anti-inflammatory cytokine interleukin-10. We showed that interleukin-10 signals directly to nociceptors to regulate their activity and upregulated genes associated with endogenous analgesia.
About the presenter
Geoffroy Laumet, PhD, completed his graduate training at the Pasteur Institute in France and postdoctoral training at MD Anderson Cancer Center in Houston. In 2019, he joined the faculty of Michigan State University as an assistant professor in the Department of Physiology and in the neuroscience program. His lab investigates the contribution of neuroimmune interactions to the transition from acute to chronic pain. His group is particularly interested in the crosstalk between anti-inflammatory cytokines and endogenous opioids. He was a recipient of a Future Leaders in Pain Research Award from the American Pain Society and is a 2020 Rita Allen Foundation scholar. You can follow him on Twitter @GeoffroyLaumet.
About the moderator
Edgar Alfonso Romero-Sandoval, MD PhD, received his medical degree from Centro Universitario de Occidente, Quetzaltenango (Universidad de San Carlos de Guatemala) in 1999 and a PhD in neuroscience from Universidad de Alcalá de Henares, Spain, in 2003. Currently, he is associate professor of anesthesiology at Wake Forest University School of Medicine, Winston-Salem, US. The Romero-Sandoval laboratory explores neuroimmune interactions in surgical and neuropathic pain and neuropathies induced by trauma, diabetes, or chemotherapy. His lab currently focuses on phenotypic changes in immune cells governed by endoplasmic reticulum or mitochondria function and dysfunction. Additionally, Dr. Romero-Sandoval studies the endocannabinoid system in the context of pain, cannabis pharmacology, and how the cannabis market in the US is shaped and could affect cannabis user patients. His laboratory uses highly translatable approaches, including nanotechnology for cell-directed gene therapies, functional assays using primary human cells, clinical data, and marketing practices analysis.
Join the conversation about the seminar on Twitter @PainResForum #PRFSeminar
We thank the Center for Advanced Pain Studies at the University of Texas at Dallas, US, for its support of the PRF seminar series.
