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Papers of the Week
YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice.
Authors
Ou C, Zhang K, Mu Y, Huang Z, Li X, Huang W, Wang Y, Zeng W, Ouyang HAbstract
Physical symptoms and aversion induced by opioid withdrawal strongly affect the management of opioid addiction. YTH N6-methyladenosine (mA) RNA binding protein 1 (YTHDF1), an mA-binding protein, from the periaqueductal gray (PAG) reportedly contributes to morphine tolerance and hyperalgesia. However, the role of YTHDF1 in morphine withdrawal remains unclear.