I am a
Home I AM A Search Login

Papers of the Week


Papers: 17 Jun 2023 - 23 Jun 2023

RESEARCH TYPE:
Clinical


Genetics, Human Studies, Neurobiology

PAIN TYPE:
Cancer Pain, Neuropathic Pain


2023 Jun 21


Genome Med


37344884


15


1

Editor's Pick

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.

Authors

Khan Z, Jung M, Crow M, Mohindra R, Maiya V, Kaminker JS, Hackos DH, Chandler GS, McCarthy MI, Bhangale T

Abstract

Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities. Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting neurological toxicity of chemotherapies with no effective approach for prevention.