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Papers of the Week


Papers: 11 Mar 2023 - 17 Mar 2023

RESEARCH TYPE:
Clinical


Human Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2023 Apr


Cephalalgia


36924253


43


4

“Wearing-off” efficacy of CGRP monoclonal antibodies for migraine prevention: A meta-analysis of randomized controlled trials.

Authors

Asawavichienjinda T, Sathitratanacheewin S, Chokesuwattanaskul R

Abstract

A new migraine prevention, CGRP monoclonal antibodies (mAbs), is injectable on a monthly or quarterly basis. In clinical practice, some patients reported that drug effectiveness does not last until the upcoming scheduled injection, a so-called “wearing-off” effect. We aimed to evaluate the wearing-off effect of the CGRP mAbs for migraine prevention in patients with different monthly migraine days.