Home / Publications / Pain Research Forum / Papers of the Week / Vortioxetine reduces the development of pain-related behaviour in a knee osteoarthritis model in rats: Involvement of nerve growth factor (NGF) down-regulation.
Vortioxetine reduces the development of pain-related behaviour in a knee osteoarthritis model in rats: Involvement of nerve growth factor (NGF) down-regulation.
Authors
Tomić M, Nastić K, Dinić M, Brdarić E, Kotur-Stevuljević J, Pecikoza U, Pavićević D, Micov A, Milenković D, Jovanović A, Stepanović-Petrović R
Abstract
Vortioxetine, a multimodal-acting antidepressant, has recently shown analgesic properties. We aimed to investigate its prophylactic effect in the osteoarthritis (OA) model and gain insights into the underlying molecular mechanisms. Duloxetine was studied as a reference.
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