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Papers of the Week

Papers: 13 Jan 2024 - 19 Jan 2024

2024 Jan 10

Microvasc Res


Vascular read-out for TRP channel functionality on distal peripheral nerve endings in healthy men.


Marynissen H, Janssen C, Bamps D, de Hoon J


Quantification of the vasodilation after topical application of capsaicin or cinnamaldehyde is often implemented to indirectly assess Transient Receptor Potential (TRP) Vanilloid 1 (TRPV1) or Ankyrin 1 (TRPA1) functionality respectively. This method has been well-established on the human forearm. However, to enable TRP functionality assessments in distal peripheral neuropathy, the vascular response upon TRP activation on dorsal finger skin was characterized.