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Papers of the Week
Vascular read-out for TRP channel functionality on distal peripheral nerve endings in healthy men.
Authors
Marynissen H, Janssen C, Bamps D, de Hoon JAbstract
Quantification of the vasodilation after topical application of capsaicin or cinnamaldehyde is often implemented to indirectly assess Transient Receptor Potential (TRP) Vanilloid 1 (TRPV1) or Ankyrin 1 (TRPA1) functionality respectively. This method has been well-established on the human forearm. However, to enable TRP functionality assessments in distal peripheral neuropathy, the vascular response upon TRP activation on dorsal finger skin was characterized.