I am a
Home I AM A Search Login

Papers of the Week


Papers: 18 Feb 2023 - 24 Feb 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular, Pharmacology/Drug Development

PAIN TYPE:
Musculoskeletal Pain


2023 Mar 01


Neuroreport


36789844


34


4

Vascular endothelial growth factor-A is involved in intramuscular carrageenan-induced cutaneous mechanical hyperalgesia through the vascular endothelial growth factor-A receptor 1 and transient receptor potential vanilloid 1 pathways.

Authors

Ueda T, Watanabe M, Miwa Y, Shibata Y, Kumamoto N, Ugawa S

Abstract

Vascular endothelial growth factor-A (VEGF-A) plays a leading role in angiogenesis and pain hypersensitivity in cancer and chronic pain. It is not only induced by ischemic conditions but is also highly correlated with proalgesic cytokines, both of which are prominent in inflammatory muscle pain. However, the molecular basis of the involvement of VEGF-A in muscle pain remains unknown.