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Papers of the Week

Papers: 2 Mar 2024 - 7 Mar 2024

2024 Mar 02

Toxicol Appl Pharmacol


Ursolic acid alleviates paclitaxel-induced peripheral neuropathy through PPARγ activation.


Yang Y, He Z, Wu S


Chemotherapy-induced peripheral neuropathy (CIPN) reduces the overall quality of life and leads to interruption of chemotherapy. Ursolic acid, a triterpenoid naturally which presents in fruit peels and in many herbs and spices, can function as a peroxisome proliferator-activated receptor γ (PPARγ) agonist, and has been widely used as an herbal medicine with a wide spectrum of pharmacological activities, including anti-cancer, anti-inflammatory and neuroprotective effect.