I am a
Home I AM A Search Login

Papers of the Week


Papers: 9 Nov 2024 - 15 Nov 2024


2024 Dec


Pain Rep


39512583


9


6

Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury-induced neuropathy in rats.

Authors

Wen ZH, Chen NF, Cheng HJ, Kuo HM, Chen PY, Feng CW, Yao ZK, Chen WF, Sung CS

Abstract

Neuropathic pain (NP) affects countless people worldwide; however, few effective treatments are currently available. Histone deacetylases (HDACs) participate in epigenetic modifications in neuropathy-induced nociceptive sensitization. Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter that can inhibit NP. The present study aimed to examine the role of spinal HDAC and its isoforms in neuropathy.