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Papers of the Week
Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis.
Authors
Xiong Z, Guo Z, Zhao L, Qiu D, Mei Y, Li X, Zhang P, Zhang M, Liu G, Gao T, , Wang Y, Yu XAbstract
Cluster headache (CH) is a highly disabling primary headache disorder with a complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical needs. This study aims to identify potential new therapeutic targets for CH through proteome-wide mendelian randomization (PWMR).