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Papers of the Week

Papers: 25 May 2024 - 31 May 2024

2024 May 24

Expert Opin Ther Pat


Type II & III inhibitors of tropomyosin receptor kinase (Trk): a 2020-2022 patent update.


Iliev P, Jaworski C, Wängler C, Wängler B, Page BDG, Schirrmacher R, Bailey JJ


The Trk family proteins are membrane-bound kinases predominantly expressed in neuronal tissues. Activated by neurotrophins, they regulate critical cellular processes through downstream signaling pathways. Dysregulation of Trk signaling can drive a range of diseases, making the design and study of Trk inhibitors a vital area of research. This review explores recent advances in the development of type II and III Trk inhibitors, with implications for various therapeutic applications.