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Papers of the Week

Papers: 21 Oct 2023 - 27 Oct 2023


Front Mol Neurosci



Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli.


Mack MR, Miron Y, Chen F, Miller PE, Zhang A, Korotzer A, Richman D, Bryce PJ


Chronic itch is a central symptom of atopic dermatitis. Cutaneous afferent neurons express receptors interleukins (IL)-4, IL-13, and IL-33, which are type 2 cytokines that are elevated in atopic dermatitis. These neuronal cytokine receptors were found to be required in several murine models of itch. Prior exposure of neurons to either IL-4 or IL-33 increased their response to subsequent chemical pruritogens in mice but has not been previously examined in humans. The objective of the present study was to determine if type 2 cytokine stimulation sensitizes sensory neurons to future itch stimuli in a fully human system.