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Papers of the Week
TRPV1-mediated sonogenetic neuromodulation of motor cortex in freely moving mice.
Authors
Xu K, Yang Y, Hu Z, Yue Y, Gong Y, Cui J, Culver JP, Bruchas MR, Chen HAbstract
Noninvasive and cell-type-specific neuromodulation tools are critically needed for probing intact brain function. Sonogenetics for noninvasive activation of neurons engineered to express thermosensitive transient receptor potential vanilloid 1 (TRPV1) by transcranial focused ultrasound (FUS) was recently developed to address this need. However, using TRPV1-mediated sonogenetics to evoke behavior by targeting the cortex is challenged by its proximity to the skull due to high skull absorption of ultrasound and increased risks of thermal-induced tissue damage.