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Papers of the Week


Papers: 4 Feb 2023 - 10 Feb 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular

PAIN TYPE:
Abdominal/Pelvic Pain


2023 Feb 05


Life Sci


36750138

TRPV1 is involved in abdominal hyperalgesia in a mouse model of lipopolysaccharide-induced peritonitis and influences the immune response via peripheral noradrenergic neurons.

Authors

Sugiyama Y, Ishida K, Yoshiyama Y, Tanaka S, Kawamata M

Abstract

The transient receptor potential vanilloid subfamily 1 (TRPV1) not only plays a role as a nociceptor but also has some regulatory effects on the immune system. We investigated the effects of TRPV1 on abdominal pain and the immune system in lipopolysaccharide (LPS)-induced peritonitis and the association between TRPV1 and peripheral noradrenergic neurons.