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Papers of the Week

Papers: 9 Dec 2023 - 15 Dec 2023

2023 Dec 10




Treatment evaluation of Rheumatoid arthritis by in situ fluorescence imaging of the Golgi cysteine.


Wang H, Wen N, Li P, Xiu T, Shang S, Zhang W, Zhang W, Qiao J, Tang B


Rheumatoid arthritis (RA) is a long-term systemic inflammatory disease that causes severe joint pain. Golgi stress caused by redox imbalance significantly involves in acute and chronic inflammatory diseases, in which cysteine (Cys), as a representative reducing agent, may be an effective biomarker for RA. Hence, in order to achieve RA early detection and drugs evaluation, based on our previous work about innovative Golgi-targeting group, we established a phenylsulfonamide-modified fluorescence probe, Golgi-Cys, for the selective fluorescence imaging of Cys in Golgi apparatus in vivo. By application of Golgi-Cys, the Cys changes under Golgi stress in cells were elucidated. More importantly, we found that the probe can be effectively utilized for the RA detection and treatment evaluation in situ.