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Papers of the Week
Transcriptomic analysis of pancreatic tissue from humans and mice identifies potential gene signatures and unexplored pathways during progression from acute to chronic pancreatitis.
Authors
Galande S, Ravikanth VV, Tokala RK, Satyanarayana Singh S, Rao GV, Talukdar R, Peddapulla C, Reddy D, Sasikala MAbstract
A comprehensive understanding of the molecular pathogenesis of chronic pancreatitis (CP), a fibroinflammatory disorder of the pancreas, is warranted for the development of targeted therapies. The current study focused on comparing the transcriptomes of pancreatic tissues obtained from patients with CP with those of two rodent models of chemically induced CP to identify dysregulated genes/signaling pathways.