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Papers of the Week

Papers: 8 Jun 2024 - 14 Jun 2024

2024 Jun 12

Eur J Pain


Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces evoked pain in healthy volunteers, a randomized, double-blind, placebo-controlled, crossover study.


Segerdahl M, Rother M, Halldin MM, Popescu T, Schaffler K


The TRPV1 receptor is a key molecule in pain generation. Previous development of oral TRPV1-antagonists was halted due to systemic heat insensitivity and body temperature alterations. The present Phase 1b study investigated the efficacy, safety and plasma exposure of a topically administered TRPV1-antagonist (ACD440 Gel) in healthy subjects.