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Papers of the Week

Papers: 1 Jun 2024 - 7 Jun 2024

2024 Jun 03

J Headache Pain




Therapeutic patterns and migraine disease burden in switchers of CGRP-targeted monoclonal antibodies – insights from the German NeuroTransData registry.


Hong JB, Israel-Willner H, Peikert A, Schanbacher P, Tozzi V, Köchling M, Reuter U, Raffaelli B


Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have shown good efficacy in migraine prophylaxis. However, a subset of patients does not respond to the first mAb treatment and switches among the available mAbs. The goal of this study is to characterize the switching pattern of migraine patients treated with anti-CGRP(-receptor, -R) mAbs, and to describe the headache burden of those who did not switch, switched once, and switched twice.