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Papers of the Week

Papers: 21 Oct 2023 - 27 Oct 2023

2023 Oct





The therapeutic effects of transferring remote ischemic preconditioning serum in rats with neuropathic pain symptoms.


Gunduz O, Yurtgezen ZG, Topuz RD, Sapmaz-Metin M, Kaya O, Orhan AE, Ulugol A


Neuropathic pain is defined as pain caused by damage to the nerve as a result of a lesion or disease. It has been shown that ischemic preconditioning exerts a protective role in various tissue injuries; however, the effect of transplantation of remote ischemic preconditioning serum (RIPCs) on neuropathic pain symptoms has not been studied. The aim of this project is to investigate the effect of RIPCs transfusion by different routes of administration on neuropathic pain symptoms. Our secondary aim was to demonstrate the role of Schwann cells in the regeneration of sciatic nerve injury and to evaluate the change in the number of glial cells in the spinal cord dorsal horn.