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Papers of the Week


Papers: 2 Sep 2023 - 8 Sep 2023

RESEARCH TYPE:
Review


Neurobiology, Pharmacology/Drug Development

PAIN TYPE:
Arthritis


2023 Sep 07


Immunotherapy


37675498

The role of upadacitinib for the treatment of axial spondyloarthritis.

Authors

George N, Liew JW, Dubreuil M

Abstract

Janus kinase inhibitors were recently approved for treatment of axial spondyloarthritis following clinical trials demonstrating benefit for symptom control. Upadacitinib treatment resulted in Assessment of SpondyloArthritis International Society 40 response improvement (defined as at least 40% improvement and an absolute improvement in global assessment of disease activity, patient assessment of back pain and other indices) in 45-52% of trial participants with axial spondyloarthritis. We review the data for efficacy and safety of upadacitinib in this patient population.