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Papers of the Week

Papers: 13 May 2023 - 19 May 2023


Human Studies, Neurobiology, Neuroimaging

Inflammation/Inflammatory, Musculoskeletal Pain

2023 May 15

J Neuroimaging


The role of the insula in chronic pain following spinal cord injury: A resting-state fMRI study.


Mandloi S, Syed M, Shoraka O, Ailes I, Kang KC, Sathe A, Heller J, Thalheimer S, Mohamed FB, Sharan A, Harrop J, Krisa L, Matias C, Alizadeh M


Spinal cord injury (SCI) results in the loss of motor and sensory function from disconnections between efferent and afferent pathways. Most SCI patients are affected with chronic neuropathic pain, but there is a paucity of data concerning neuroplastic changes following SCI. Chronic pain disrupts default networks and is associated with abnormal insular connectivity. The posterior insula (PI) is associated with the degree of pain and intensity of pain. The anterior insula (AI) is related to signal changes. Comprehension of SCI pain mechanisms is essential to elucidate effective treatment options.