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Papers of the Week
The relationship between clinical phenotype and kallikrein-kinin bioregulation in different forms of arthritis.
Authors
Tan DBA, Tedja C, Kuster L, Raymond WD, Harsanyi A, Chowalloor PV, Misso NL, Argawal S, Bhoola KD, Keen HIAbstract
Patients with rheumatoid arthritis (RA) have shown increased levels of neutrophils generating kallikrein-kinin peptides in blood which are potent mediators of inflammation. This study investigated the association between the bioregulation of kinin-mediated inflammation with the clinical, quality of life, and imaging characteristics (e.g. ultrasonography) of different arthritides.