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Papers of the Week
The Relationship Between Chronic Postoperative Pain and Circulating Inflammatory Biomarkers (CC-Chemokine Ligand 5, Adiponectin, and Resistin) After Fracture-Related Surgery in Pain Chronification.
Authors
Malewicz-Oeck NM, Aulenkamp JL, Oeck S, Scheffzük C, Zahn PK, Hansen W, Schramm A, Meyer-Frießem CHAbstract
After fracture-related surgery, chronic posttraumatic and/or postsurgical pain (CPSP) has a high incidence rate of up to 43% a year after surgery. Yet the underlying mechanisms are poorly understood. Murine and clinical evidence suggest immunological modulation of postsurgical pain. However, the specific cytokine profiles of patients who develop CPSP after fracture-related surgery remain to be determined. Therefore, we analyzed in an exploratory manner cytokines, chemokines and adipocytokines in patients with and without CPSP up to 1 year after fracture-related surgery.