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Papers of the Week

Papers: 8 Jun 2024 - 14 Jun 2024

2024 Jun 10

Expert Opin Drug Discov


The preclinical discovery and development of atogepant for migraine prophylaxis.


Baraldi C, Beier D, Martelletti P, Pellesi L


Atogepant is a selective calcitonin gene-related peptide (CGRP) receptor antagonist that is utilized in adults for the prevention of episodic and chronic migraine. Cumulative findings support the involvement of CGRP in migraine pathophysiology, and atogepant functions by competitively antagonizing CGRP receptors, which results in the inhibition of trigeminovascular nociception. The mechanism of action addresses the cause of migraine pain, providing an effective preventive treatment option.