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Papers of the Week


Papers: 25 Jan 2025 - 31 Jan 2025


2025 Jan 27


Br J Anaesth


39875287

The number of central nervous system-driven symptoms predicts subsequent chronic primary pain: evidence from UK Biobank.

Authors

Kelleher E, Kaplan CM, Kheirabadi D, Schrepf A, Tracey I, Clauw DJ, Irani A

Abstract

Chronic primary pain describes conditions where pain is the principal problem rather than a consequence of another disease. Primary pain is thought to be primarily owing to nociplastic pain (i.e. pain as a result of altered nociception despite the absence of tissue damage). Primary pain is often accompanied by other bothersome central nervous system (CNS)-driven symptoms, including disturbed sleep, mood, and cognition; however, it is unclear whether these symptoms precede onset of primary pain.