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Papers of the Week
The NGF/TrKA pathway enhances analgesia in an experimental mice model of bone cancer pain by increasing membrane levels of δ-opioid receptors.
Authors
Kan BF, Liu XY, Han MM, Yang CW, Zhu X, Jin Y, Wang D, Huang X, Wu WJ, Fu T, Kang F, Zhang Z, Li JAbstract
The role of Nerve growth factor (NGF)/tyrosine kinase A receptor (TrKA) signaling, which is activated in a variety of pain states, in regulating membrane-associated δ-opioid receptor (mDOR) expression is poorly understood. We hypothesized that elevated NGF in bone cancer tumors could upregulate mDOR expression in spinal cord neurons, and that mDOR agonism might alleviate bone cancer pain (BCP).