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Papers of the Week

Papers: 30 Sep 2023 - 6 Oct 2023

2023 Sep

JOR Spine




The influence of intervertebral disc overloading on nociceptor calcium flickering.


Gewiess J, Eglauf J, Soubrier A, Grad S, Alini M, Peroglio M, Ma J


Mechanical overloading can trigger a degenerative-like cascade in an organ culture of intervertebral disc (IVD). Whether the overloaded IVD can influence the activation of nociceptors (i.e., the damage sensing neurons) remains unknown. The study aims to investigate the influence of overloaded IVD conditioned medium (CM) on the activation of nociceptors.