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Papers of the Week

Papers: 4 May 2024 - 10 May 2024

2024 May 03



The impact of the migraine treatment onabotulinumtoxinA on inflammatory and pain responses: Insights from an animal model.


Reducha PV, Bömers JP, Edvinsson L, Haanes KA


Migraine, a prevalent and debilitating disease, involves complex pathophysiology possibly including inflammation and heightened pain sensitivity. The current study utilized the complete Freund’s adjuvant (CFA) model of inflammation, with onabotulinumtoxinA (BoNT/A) as a treatment of interest due to its use in clinical migraine management. Using an animal model, the study sought to investigate the role of BoNT/A in modulating CFA-induced inflammation, alterations in pain sensitivity, and the regulation of calcitonin gene-related peptide (CGRP) release. Further, we aimed to assess the changes in SNAP-25 through western blot analysis to gain insights into the mechanistic action of BoNT/A.