Climate change is a global threat to public health and causes/worsens various diseases including atopic dermatitis (AD), allergic, infectious, cardiovascular diseases, physical injuries and mental disorders. The incidence of allergy, such as AD, has increased over the last several decades, and environmental factors such as climate change have been implicated as a potential mechanism. A significant amount of literature has been published on the impact of climate factors, including cold and hot temperature, on the skin barrier and AD. Studies in several countries have shown a greater incidence of AD in children born in the colder seasons of fall and winter. The effect of cold and warm temperature on itch, skin flares, increased outpatient visits, skin barrier dysfunction, development of AD, and asthma exacerbations have been reported. Understanding mechanisms by which changes in temperature influence allergies is critical to the development of measures for prevention and treatment of allergic disorders, such as AD and asthma. Low and high temperature induce production of proinflammatory cytokines and lipid mediators such as IL-1beta, thymic stromal lymphopoietin (TSLP), and prostaglandin E2, and cause itch and flares by activation of transient receptor potential vanilloid channels (TRPVs) such as TRPV1, TRPV3, and TRPV4. TRPV antagonists may attenuate temperature-mediated itch, skin barrier dysfunction, and exacerbation of AD.