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Papers of the Week
The Efficacy and Safety of Botulinum Neurotoxin Type A in Treating Chronic Low Back Pain: A Systematic Review, Meta-Analysis, Trial Sequential Analysis, and Meta-Regression.
Authors
Wagrees W, Kelani H, Salamah HM, Mahmoud A, Khlidj Y, Abdelraouf MR, Sharaf B, Elnewishy M, Albaramony N, Naeem A, Elazim AA, El-Ghanem M, Greene-Chandos D, Jadidi M, Lerner DP, Kay AD, Merlin LR, Brock CAbstract
Chronic low back pain (CLBP) is a leading cause of disability. Botulinum neurotoxin type A (BoNT-A) has strong anti-spasmodic and analgesic effects, suggesting that its local muscular injection can reduce CLBP compared to other therapies. In this systematic review and meta-analysis, we investigated the efficacy and safety of BoNT-A on patients with CLBP.