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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2025


PLoS One


39823469


20


1

The effects of lowering barometric pressure on pain behavior and the stress hormone in mice with neuropathic pain.

Authors

Terajima Y, Sato J, Inagaki H, Ushida T

Abstract

Lowering barometric pressure (LP) can exacerbate neuropathic pain. However, animal studies in this field are limited to a few conditions. Furthermore, although sympathetic involvement has been reported as a possible mechanism, whether the sympathetic nervous system is involved in the hypothalamic-pituitary-adrenal (HPA) axis remains unknown. To address these issues, we investigated LP-induced hyperalgesia by focusing on the cumulative effect of LP and measuring plasma corticosterone levels as a marker of HPA axis activation in mice.