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Papers of the Week
The effect of sex and estrus cycle stage on optogenetic spreading depression induced migraine-like pain phenotypes.
Authors
Harriott AM, Waruinge A, Appiah-Danquah V, Berhanu L, Morais A, Ayata CAbstract
Migraine is more prevalent in females, raising the possibility that sex and gonadal hormones modulate migraine. We recently demonstrated that minimally invasive optogenetic spreading depolarization (opto-SD) elicits robust periorbital allodynia. The objective of this study was to test the hypothesis that opto-SD induced migraine-like pain behavior is worse in females and varies during the estrus cycle.