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Papers of the Week

Papers: 22 Apr 2023 - 28 Apr 2023

Pediatric, Psychology, Review

Human Studies, Neurobiology


2023 Apr 20

Br J Anaesth


The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.


Antoniou G, Lambourg E, Steele JD, Colvin LA


Adverse childhood experiences have been linked to increased multimorbidity, with physical and mental health consequences throughout life. Chronic pain is often associated with mood disorders, such as major depressive disorder (MDD); both have been linked to adverse childhood experiences. It is unclear how the effect of adverse childhood experiences on neural processing impacts on vulnerability to chronic pain, MDD, or both, and whether there are shared mechanisms. We aimed to assess evidence for central neural changes associated with adverse childhood experiences in subjects with chronic pain, MDD, or both using systematic review and meta-analysis.