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Papers of the Week

Papers: 2 Mar 2024 - 7 Mar 2024

2024 Mar 05

J Headache Pain




The crucial role of locus coeruleus noradrenergic neurons in the interaction between acute sleep disturbance and headache.


Li B, Cao Y, Yuan H, Yu Z, Miao S, Yang C, Gong Z, Xie W, Li C, Bai W, Tang W, Zhao D, Yu S


Both epidemiological and clinical studies have indicated that headache and sleep disturbances share a complex relationship. Although headache and sleep share common neurophysiological and anatomical foundations, the mechanism underlying their interaction remains poorly understood. The structures of the diencephalon and brainstem, particularly the locus coeruleus (LC), are the primary sites where the sleep and headache pathways intersect. To better understand the intricate nature of the relationship between headache and sleep, our study focused on investigating the role and function of noradrenergic neurons in the LC during acute headache and acute sleep disturbance.