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Papers of the Week
The concerted actions of microRNA-29a and interferon-β modulate complete Freund’s adjuvant-induced inflammatory pain by regulating the expression of type 1 interferon receptor, interferon-stimulated gene 15, and p-extracellular signal-regulated kinase.
Authors
Liu CC, Hung KC, Li YY, Yi-Kung Huang E, Chu CC, Chow LH, Tan PHAbstract
Previous research has shown that type 1 interferons (IFN), such as IFN-α and IFN-ß, possess antiviral and antinociception effects. Elevated levels of microRNA-29a (miR-29a) have been observed during inflammatory pain, and as miR-29a targets the type 1 IFN receptor (IFNR1), our study aimed to investigate the involvement of miR-29a, type 1 IFN, and IFNR1 in inflammatory pain.