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Papers of the Week
Targeting the TRPV1 pain pathway in osteoarthritis of the knee.
Authors
Mobasheri A, Rannou F, Ivanavicius S, Conaghan PGAbstract
The growing prevalence and lack of effective pain therapies for knee osteoarthritis (KOA) results in a substantial unmet need for novel analgesic therapies. The transient receptor potential vanilloid 1 (TRPV1) receptor is expressed in subsets of nociceptive sensory neurons and has major roles in pain transmission and regulation. In the structures of the knee joint, nociceptors are present in abundance.