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Papers of the Week
Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice.
Authors
Zaninelli TH, Fattori V, Heintz OK, Wright KR, Bennallack PR, Sim D, Bukhari H, Terry KL, Vitonis AF, Missmer SA, Andrello AC, Anchan RM, Godin SK, Bree D, Verri WA, Rogers MSAbstract
Endometriosis is a chronic inflammatory disease that affects ∼ 10 % of women. A significant fraction of patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits increased neurite and vascular density, suggesting that disease pathology involves neurotrophic activity and angiogenesis.