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Papers of the Week

Papers: 17 Feb 2024 - 23 Feb 2024

2024 Feb 17

Arthritis Res Ther




Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain.


Pandey A, Singla M, Geller A, Goodman SB, Bhutani N


Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which they reside will elucidate new therapeutic approaches for pain management. Our recent studies had identified an inflammation-amplifying (Inf-A) cell population that is expanded in human OA cartilage and is distinctive in the expression of both IL1R1 and TNF-R2 receptors and active Jnk signaling cascade.