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Targeted Muscle Reinnervation (TMR) is an effective technique for the prevention and management of phantom limb pain (PLP) and residual limb pain (RLP) among amputees. The purpose of this study was to evaluate symptomatic neuroma recurrence and neuropathic pain outcomes between cohorts receiving TMR at the time of amputation (i.e., acute) versus TMR following symptomatic neuroma formation (i.e., delayed).