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Papers of the Week


Papers: 11 Jan 2025 - 17 Jan 2025


2025 Jan 13


Anesthesiology


39804333

TAK-925 (danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-Induced Respiratory Depression and Sedation Without Affecting Analgesia in Healthy Adult Males.

Authors

van Lemmen M, Dahan A, Hang Y, Jansen SC, Lu H, Naylor M, Olsson T, Sheikh S, Sullivan D, Tolkoff M, van der Schrier R, van Velzen M, von Rosenstiel P, Wu RL, Meyer S

Abstract

Orexin neuropeptides help regulate sleep/wake states, respiration, and pain. However, their potential role in regulating breathing, particularly in perioperative settings, is not well understood. TAK-925 (danavorexton), a novel, orexin receptor 2-selective agonist, directly activates neurons associated with respiratory control in the brain and improves respiratory parameters in rodents undergoing fentanyl-induced sedation. This study assessed the safety and effect of danavorexton on ventilation in healthy men in an established remifentanil-induced respiratory depression model.