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Papers of the Week

Papers: 29 Jul 2023 - 4 Aug 2023


Front Pharmacol



T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions.


Rangel-Galván M, Rangel-Galván V, Rangel-Huerta A


Neuropathic pain can appear as a direct or indirect nerve damage lesion or disease that affects the somatosensory nervous system. If the neurons are damaged or indirectly stimulated, immune cells contribute significantly to inflammatory and neuropathic pain. After nerve injury, peripheral macrophages/spinal microglia accumulate around damaged neurons, producing endogenous hydrogen sulfide (HS) through the cystathionine-γ-lyase (CSE) enzyme. HS has a pronociceptive modulation on the Ca3.2 subtype, the predominant Ca3 isoform involved in pain processes. The present review provides relevant information about HS modulation on the Ca3.2 T-type channels in neuropathic pain conditions. We have discussed that the dual effect of HS on T-type channels is concentration-dependent, that is, an inhibitory effect is seen at low concentrations of 10 µM and an augmentation effect on T-current at 100 µM. The modulation mechanism of the Ca3.2 channel by HS involves the direct participation of the redox/Zn affinity site located in the His191 in the extracellular loop of domain I of the channel, involving a group of extracellular cysteines, comprising C114, C123, C128, and C1333, that can modify the local redox environment. The indirect interaction pathways involve the regulation of the Ca3.2 channel through cytokines, kinases, and post-translational regulators of channel expression. The findings conclude that the CSE/HS/Ca3.2 pathway could be a promising therapeutic target for neuropathic pain disorders.