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Papers of the Week
Supraspinal neuroinflammation and anxio-depressive-like behaviors in young- and older- adult mice with osteoarthritis pain: the effect of morphine.
Authors
Amodeo G, Franchi S, D'Agnelli S, Galimberti G, Baciarello M, Bignami EG, Sacerdote PAbstract
Asteoarthritis (OA) is a leading cause of chronic pain in the elderly population and is often associated with emotional comorbidities such as anxiety and depression. Despite age is a risk factor for both OA and mood disorders, preclinical studies are mainly conducted in young adult animals.